Harnessing the 'Omics Revolution to Investigate Drug Response and Resistance Mechanisms in Giardia Duodenalis

Grant number: LP120200122 | Funding period: 2012 - 2017

Completed

Abstract

This international research project will harness cutting-edge technologies to explore how Giardia, a major global cause of diarrhoeal illness in humans, responds to and becomes resistant to key anti-giardial drugs, providing valuable information for drug preservation and development.

Related publications (2)

Transcriptomics indicates active and passive metronidazole resistance mechanisms in three seminal Giardia lines

BRE Ansell, L Baker, SJ Emery, MJ McConville, SG Svärd, RB Gasser, AR Jex

2017-03-17

Giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. Metronidazole (Mtz) is a ..

Divergent transcriptional responses to physiological and xenobiotic stress in Giardia duodenalis

BRE Ansell, MJ McConville, L Baker, PK Korhonen, SJ Emery, SG Svärd, RB Gasser, AR Jexa

2016-10-01

Understanding how parasites respond to stress can help to identify essential biological processes. Giardia duodenalis is a parasit..

University of Melbourne Researchers

Malcolm McConville

Aaron Jex